Although both methods use high energy radiation, stereotactic radiosurgery differs from traditional radiation therapy or intensity modulated radiation therapy in several ways. CyberKnife treatments are more accurate due to the ability of the robot to point to the target from more than 1,000 possible positions with sub millimeter precision. This means that the target can be fully treated while minimizing radiation to immediately adjacent structures. High accuracy enables a full treatment in 1 to 5 sessions rather than 25 to 40 sessions.
CyberKnife is "patient centric" meaning that the system finds and then adjusts itself to the location of the patient and tumor. There is a much wider variety of treatment angles and fields for the computer to choose from. Gamma Knife radiosurgery and linear accelerator (gantry) based treatments are "isocentric" meaning that the target must be brought into the center or focal point of the treatment device. A rigid head frame is required for gantry based or Gamma Knife radiosurgery, which is confined to targets within the brain. CyberKnife does not require the use of a rigid frame so targets can be treated throughout the body.